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Puberty syndrome is a mysterious syndrome that only affects those who enter puberty. For example in the case of Sakuta Azusagawa who suddenly saw a bunny girl. Bunny girl is actually Mai Sakurajima, a famous actress who has been on hiatus from the entertainment world. For various reasons, people around Mai can't see her figure as a bunny girl. When Mai tried to solve the mystery, people with other puberty syndromes began to appear.